Risk factors analysis for bacteria discharge of pulmonary tuberculosis

Abstract

TB patients with bacteria discharge have higher risk of infectivity and spread of TB, but little is known of risk factors for bacteria discharge in the China border region. We aimed to discuss the predictors for bacteria discharge in pulmonary TB (PTB) patients. Over 47-month period a retrospectivestudy was done on 3669 consecutive PTB patients. Predictors of bacteria discharge in PTB were identified by univariate and multivariate logistic regression analysis. The c statistic was calculated to assess the discriminatory ability of the multivariate logistic regression model to predict bacteria discharge. The overall incidence of bacteria discharge in PTB was 32.24%. Underweight (OR 5.14, 95% CI 1.56-16.28), smoking history (OR 2.00, 95% CI 1.12-3.56), cavity (OR 2.57, 95% CI 1.22-8.56), low BMI (OR 1.51, 95% CI 1.05-2.16) and hypoproteinemia (OR 1.58, 95% CI 1.06-2.35) were positively associated and pleural effusion (OR 0.30, 95% CI 0.18-0.48) was negatively associated with bacteria discharge in PTB patients. Underweight, smoking history, cavity, low BMI and hypoproteinemia are the independent factors for TB bacterial discharge. Early identification of PTB patients that susceptible to bacteria discharge may contribute to controlling source of infection in time and reduce the spread of TB.

Keywords: Tuberculosis (TB),bacteria discharge, risk factor