The study of brain natriuretic peptide level and heart rate turbulence in acute coronary syndrome

Abstract

This study aims to investigate the effect of serum brain natriuretic peptide (BNP) level and heart rate turbulence (HRT) phenomena on changes in acute coronary syndrome (ACS) patients, and their roles in predicting the evaluation of recent cardiovascular event. According to clinical diagnosis and coronary artery angiography results, 102 patients were divided into three groups; ST-elevation myocardial infarction (STEMI), non ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA). The BNP and HRT results were determined upon performance of parallel color doppler ultrasound examination. Major adverse cardiac events (MACE) during hospitalization and within 90 days after discharge were analyzed. BNP level significantly differed between ACS and control groups (P < 0.05). With ACS degree aggravating, the classification of HRT in HRT2 increased significantly. Comparisons between with and without MACE shows an increase in BNP level, HRT2 ratio and Turbulence Onset (TO) with a decrease in turbulence slope (TS). The levels of BNP in patients with ACS are good indicators of the severity of ACS. HRT phenomenon is associated with ACS type. BNP and HRT are correlated with recent adverse cardiovascular events

Keywords: acute coronary syndrome, brain natriuretic peptide, heart rate turbulence, major adverse cardiac events.