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Adilson Renato VeríssimoEdison Endara
Gerardine Leal
Valeria León
Cristina Solis
Elizabeth Parker
Santiago Rodriguez
Case Study
Liver injury induced by intravenous phenytoin and the benefit of Roussel Uclaf Causality assessment method score: A case report
Adilson Renato Veríssimo1, Edison Endara2, Gerardine Leal3,4, Valeria León3,4, Cristina Solis3,4, Elizabeth Parker3,4 and Santiago Rodriguez* 4,5
1Department of Gastroenterology, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Minas Gerais, Brazil
2Department of Emergency, Hospital Vozandes Quito – HVQ SA, Quito 170521, Ecuador
3Postgraduate Program in Family Medicine, School of Medicine, Pontifical Catholic University of Ecuador, Quito 170143, Ecuador
4Department of Hepatology, Hospital Vozandes Quito – HVQ SA, Quito 170521, Ecuador
5Graduate Program in Medicine: Hepatology, School of Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil
*Corresponding Author Email: santy_rodri03(at)yahoo.com
Adilson Renato Veríssimo |
Edison Endara |
Gerardine Leal |
Valeria León |
Cristina Solis |
Elizabeth Parker |
Santiago Rodriguez |
Article Number: irjpeh.21.026 | Pages: 253-258 | Vol. 8 (4), July 2021 | DOI: https://doi.org/10.15739/irjpeh.21.026
Received: May 13, 2021 Accepted: June 18, 2021 Published: July 15, 2021
Abstract
Drug-induced liver injury (DILI) and its diagnosis are difficult in clinical practise, and despite the development of a specific scoring system to assess its causality via the CIOMS/RUCAM score (Council for International Organizations of Medical Sciences/ Roussel Uclaf Causality Assessment Method), its diagnosis remains rare. The bulk of reported instances of DILI are connected to oral medicines, and DILI induced by intravenous medication is uncommon in clinical practise. The following case report concerns an adult who came with a generalised tonic-clonic seizure without an identified inciting cause and had no prior medical history or recent ingestion of prescription medication. The patient had severe hepatitis, thrombocytopenia, and hyperbilirubinemia after taking phenytoin. All acute hepatic diseases were ruled out, and the patient was found to have an RUCAM score of 9, indicating drug-induced liver damage from parenteral medicine. Close monitoring of patients in complicated clinical settings, such as hospital wards, and examination of all differential diagnoses aid in the identification of cases of DILI induced by parenteral drugs.
Keywords:
Drug-induced liver injury, hepatotoxicity, intravenous, phenytoin, roussel uclaf causality assessment method, Case report, antiepileptic drug
How to Cite this Article
Veríssimo AR, Endara E, Leal G, León V, Solis C, Parker E, Rodriguez S (2021). Liver injury induced by intravenous phenytoin and the benefit of Roussel Uclaf Causality assessment method score: A case report. Int. Res. J. Pub. Environ. Health 8(4):253-258.
Author(s) retain the copyright of this article. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.