Search for Articles on Google by:
Elizondo-Plazas AnasofiaMartinez-de-Villarreal Laura E
Cárdenas-Ramos Susana G
Rojas-Patlan Luz
Velasco-Sepulveda Braulio H
Elizondo-Riojas Guillermo
Velasco-Campos Ma. Del Roble
Original Research Article
Effects of ionizing radiation in DNA: Defining the immediate and cumulative genetic damage induced by head computed tomography
Elizondo-Plazas Anasofia1, Martinez-de-Villarreal Laura E1, Cárdenas-Ramos Susana G1, Rojas-Patlan Luz1, Velasco-Sepulveda BraulioH2, Elizondo-Riojas Guillermo3, and Velasco-Campos Ma. Del Roble*1
1Departamento de Genética. Facultad de Medicina y Hospital Universitario “Dr. José E. González”. Av. Gonzalitos Col. Mitras Centro, Monterrey, N.L. CP 64460, México.
2Universidad Autónoma de Nuevo León, Facultad de Medicina, Subdirección de Investigación. Ave. Madero y Dr. E. Aguirre Pequeño s/n, Mitras Centro, Monterrey, N.L. C.P. 64460, Mexico.
3Departamento de Radiología. Hospital Universitario “Dr. José E. González”. Ave. Madero y Av. Gonzalitos Col. Mitras Centro, Monterrey, N.L. CP 64460, México.
*Corresponding Author E-mail: roble.velazco(at)gmail.com
Elizondo-Plazas Anasofia |
Martinez-de-Villarreal Laura E |
Cárdenas-Ramos Susana G |
Rojas-Patlan Luz |
Velasco-Sepulveda Braulio H |
Elizondo-Riojas Guillermo |
Velasco-Campos Ma. Del Roble |
Article Number: irjpeh.22.018 | Pages: 148-155 | Vol. 9 (5), December 2022 | DOI: https://doi.org/10.15739/irjpeh.22.018
Received: September 3, 2022 Accepted: November 4, 2022 Published: December 5, 2022
Abstract
Nowadays, the classic way of evaluating patients with a thorough anamnesis and physical examination has been easily replaced by new diagnostic tools and its use has also increased exponentially, even when it is not fully indicated. Some imaging studies are a good example of this, recalling that exposure to ionizing radiation (IR) is its main basis. This physical agent has a direct negative effect on human DNA and its cumulative effect has not yet been studied in patients who undergo this exposure repeatedly. An observational and prospective study was conducted, where micronucleus (MN) from buccal epithelium were analyzed before and after performing head computed tomography (CT) on patients that required consecutive scans. This study showed a significant MN frequency increase in 81.25% of the analyzed patients, being 31.5% of this the group with the most descriptive significance, as they were those who were exposed to repeated doses of radiation. This study provides an approach to the relationship between immediate radiation exposure and DNA alteration as an increase in MN was observed after exposure to IR in patients undergoing to CT, demonstrating that the oral epithelium is a highly sensitive biological dosimeter and can be used for early detection of DNA damage caused by exposure to low doses of IR.
Keywords: DNA damage, micronucleus, ionizing radiation, computed tomography.
How to Cite this Article
Elizondo-Plazas A, Martinez-de-Villarreal LE, Cárdenas-Ramos SG, Rojas-Patlan L, Velasco-Sepulveda BH, Elizondo-Riojas G, Velasco-Campos MDR (2022). Effects of ionizing radiation in DNA: Defining the immediate and cumulative genetic damage induced by head computed tomography.Int. Res. J. Pub. Environ. Health 9(5):148-155.
© 2022 The authors.
This is an Open Access article that is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which allow unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.