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Valerie Flore DONKENG DONFACKYves Le Grand NAPA TCHUEDJI
Suzanne Magloire ONGBOULAL
Sorelle NGUIMFACK
Brenda SHILE
Yannick Patrick ASSOLO
Stanley NKEMNJI AWUNGAFAC
Henri MANGA
Krystel K. EBO
Edwige BELINGA
Annie NGONO BISSO
Sara EYANGOH
Original Research Article
Effectiveness of TB-LAMP in diagnosis of tuberculosis among HIV-infected persons in Cameroon
Valerie Flore DONKENG DONFACK1*, Yves Le Grand NAPA TCHUEDJI1, Suzanne Magloire ONGBOULAL1, Sorelle NGUIMFACK1, Brenda SHILE1, Yannick Patrick ASSOLO1, Stanley NKEMNJI AWUNGAFAC1, Henri MANGA2, Krystel K. EBO2, Edwige BELINGA2, Annie NGONO BISSO2 and Sara EYANGOH3
1Mycobacteriology Unit, National Tuberculosis Reference Laboratory, Centre Pasteur du Cameroun, Yaoundé, Cameroon
2National Tuberculosis Control Program, Cameroon
3Centre Pasteur du Cameroon, Yaoundé, Cameroon
*Corresponding Author E-mail: donkeng(at)pasteur-yaounde.org
Tel+237674629287
Valerie Flore DONKENG DONFACK |
Yves Le Grand NAPA TCHUEDJI |
Suzanne Magloire ONGBOULAL |
Sorelle NGUIMFACK |
Brenda SHILE |
Yannick Patrick ASSOLO |
Stanley NKEMNJI AWUNGAFAC |
Henri MANGA |
Krystel K. EBO |
Edwige BELINGA |
Annie NGONO BISSO |
Sara EYANGOH |
Article Number: irjpeh.23.007 | Pages: 69-75 | Vol. 10 (2), June 2023 | DOI: https://doi.org/10.15739/irjpeh.23.007
Received: March 24, 2023 Accepted: May 6, 2023 Published: June 4, 2023
Abstract
The diagnosis of tuberculosis (TB) is still challenging in primary healthcare settings particularly in people living with HIV (PLHIV). The Xpert MTB/RIF assay which is the point of care WHO recommended rapid diagnosis (WRD) test for TB diagnosis in PLHIV remains difficult to implement in resource limited settings. This study aimed to evaluate the performance of TB-LAMP test to diagnose TB in PLHIV. Over a 6-month period we conducted a retrospective study using 668 files of patients previous diagnosed for TB and HIV. Multivariate analysis was performed by R software to compare TB-LAMP test, Xpert MTB/Rif assay and Microscopy. Findings of the study revealed that TB-LAMP has a good sensitivity (80%, 95% CI: 68-89) and specificity (88%, 95% CI: 81-93) among HIV persons. Microscopy presented a sensitivity of 52% (95% CI: 39-64) and a specificity of 94% (95% CI: 89-98) while Xpert MTB/RIF has a sensitivity of 91% (95% CI: 81-96) and a specificity of 91% (95% CI: 85-95). There was no significant difference between TB-LAMP and Xpert MTB/RIF. The sensitivity (89%, 95% CI: 79-96) and specificity (98%, 95% CI: 92-100) of TB-LAMP in non-HIV persons were similar to those of PLHIV. TB-LAMP test displayed good performance among PLHIV and can be recommended for TB diagnosis in PLHIV.
Keywords: Effectiveness, TB-LAMP, diagnosis, performance, tuberculosis, HIV-infected persons
How to Cite this Article
Donkeng Donfack VF, Napa Tchuedji YLG, Ongboulal SM, Nguimfack S, Shile B, Assolo YP, Nkemnji Awungafac S, Manga H, Ebo KK, Belinga E, Ngono Bisso A Eyangoh S(2023). Effectiveness of TB-LAMP in diagnosis of tuberculosis among HIV-infected persons in Cameroon. Int. Res. J. Public Environ. Health DOI: https://doi.org/10.15739/irjpeh.23.007
© 2023 The authors.
This is an Open Access article that is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which allow unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.