Original Research Article
The role of obesity in JAK2 V617F gene mutation among patients with recurrent pregnancy loss
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*Corresponding Author Email: hala_awadalla(at)yahoo.com
Hala Awadallah*1 |
Mai Shaker2 |
Khaled Gaber2 |
Khalda Amr3 |
Article Number: irjpeh.18.002 | Pages: 8-12 | Vol.5 (1), January 2018 | DOI: https://doi.org/10.15739/irjpeh.18.002
Received: November 4, 2017 Accepted: December 18, 2017 Published: January 31, 2018
Abstract
Maternal obesity is one of the factors that have a role in recurrent pregnancy loss (RPL). This research deals with fetal loss in obese pregnant women that might be due the mutation in Janus kinase2 gene (V617F). The main purpose of this article is to explore the association of obesity with JAK2 V617F mutation in recurrent pregnancy loss. This study is carried out on 250 women, the case group with a history of recurrent pregnancy loss and a body mass index (BMI) >24.9kg/m2. Control group consists of women with normal body mass index and have at least one live child and with no history of pregnancy loss. All subjects were investigated for the mutations by using the allele-specific multiplex PCR. Women in the study who were obese and tested positive for JAK2 V617F were 14 %. 9.3% of patients in the case had a BMI with mean of 30.9 ±4.3. In conclusion the study suggests a correlation between the increased risk for the occurrence of RPL in obese women and the investigated V617F mutation in the Jak2 gene exon 12, this research demonstrates the feasibility that obesity could be a modifiable risk factor for that somatic mutation.
Keywords: RPL, Obesity, Gene (V617F)
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