International Research Journal of Public and Environmental Health






Search for Articles on Google by:
Ardawan F. Ali
Hivi M. Mahmoud
Dhia J. Al-Timimi



Search for Related Articles:
On Google
On Google Scholar




Original Research Article

Effects of Cigarette Smoking on DNA damage in male population in Duhok (Iraq): Relation to vitamin D status

Ardawan F. Ali1, Hivi M. Mahmoud*2 and Dhia J. Al-Timimi3


1Department of Medical Lab. Technology, Shekhan Technical College of Health, Duhok Polytechnic University. Duhok, Kurdistan Region, Iraq.
2Department of Medical Chemistry, College of Medicine, University of Duhok, Duhok,Kurdistan Region, Iraq
3Clinical Biochemistry, Department of Medical Chemistry, College of Medicine, University of Duhok, Duhok, Kurdistan Region, Iraq.

Corresponding Author Email:jody79hivi(at)yahoo.com

Tel.:+9647504667781

Ardawan F. Ali

Hivi M. Mahmoud

Dhia J. Al-Timimi


Article Number: 10.15739/irjpeh.21.004  |   Pages: 29-32  |   Vol. 8 (1), January 2021   |   DOI: https://doi.org/10.15739/irjpeh.21.004

 Received: October 5, 2020  Accepted: December 18, 2020  Published: January 9, 2021

Abstract

Prior studies have reported cigarette smoking may induce oxidative DNA damage among healthy individuals. This study aimed to determine the extent of oxidative DNA damage and to ascertain its relevance to vitamin D status in smoker and non-smoker healthy males. Observational cross-sectional study was conducted between September 2018 and March 2019. Consecutively, men who attended out-Patient Department (OPD) of Department of Medicine at Azadi Teaching Hospital as attendant of patients and healthy hospital’s staffs were selected. Body mass index, 8-hydroxy-2-deoxiguanosine (8-OHdG), an oxidative DNA damage marker and 25-hydroxyvitamin D [25(OH)D] were measured in all study subjects. Total of 410 apparently healthy volunteers were enrolled in this study. According to smoking habit, 170(41.4%) of the participants were found smokers and 240(58.6%) were non-smokers. Significantly higher 8-OHdG (P<0.001), together with lower 25(OH)D levels(p<0.015) were found in smokers compared to non-smokers. In the smoker group, 8-OHdG negatively correlated with 25(OH)D (r= -0.35,p=0.010). In the non-smoker group, we also observed a negative correlation with 25(OH)D (r= -0.46 p=0.010). Elevated 8-OHdG levels in conjunction with low vitamin D status strongly associated with smoking habit. Efforts to quit smoking with increasing vitamin D levels in this group may help to correct abnormal levels of 8-OHdG and reducing DNA damage.

Keywords:

DNA damage, cigarette smoking, vitamin D, male population.

How to Cite this Article

Ali AF, Mahmoud HM, Al-Timimi DJ (2021). Effects of Cigarette Smoking on DNA damage in male population in Duhok (Iraq): Relation to vitamin D status. Int. Res. J. Pub. Environ. Health 8(1):29-32.

Author(s) retain the copyright of this article. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.


Select Language »