Original Research Article
Effects of Cigarette Smoking on DNA damage in male population in Duhok (Iraq): Relation to vitamin D status
Ardawan F. Ali1, Hivi M. Mahmoud*2 and Dhia J. Al-Timimi3
1Department of Medical Lab. Technology, Shekhan Technical College of Health, Duhok Polytechnic University. Duhok, Kurdistan Region, Iraq.
2Department of Medical Chemistry, College of Medicine, University of Duhok, Duhok,Kurdistan Region, Iraq
3Clinical Biochemistry, Department of Medical Chemistry, College of Medicine, University of Duhok, Duhok, Kurdistan Region, Iraq.
Corresponding Author Email:jody79hivi(at)yahoo.com
Tel.:+9647504667781
Ardawan F. Ali |
Hivi M. Mahmoud |
Dhia J. Al-Timimi |
Article Number: 10.15739/irjpeh.21.004 | Pages: 29-32 | Vol. 8 (1), January 2021 | DOI: https://doi.org/10.15739/irjpeh.21.004
Received: October 5, 2020 Accepted: December 18, 2020 Published: January 9, 2021
Abstract
Prior studies have reported cigarette smoking may induce oxidative DNA damage among healthy individuals. This study aimed to determine the extent of oxidative DNA damage and to ascertain its relevance to vitamin D status in smoker and non-smoker healthy males. Observational cross-sectional study was conducted between September 2018 and March 2019. Consecutively, men who attended out-Patient Department (OPD) of Department of Medicine at Azadi Teaching Hospital as attendant of patients and healthy hospital’s staffs were selected. Body mass index, 8-hydroxy-2-deoxiguanosine (8-OHdG), an oxidative DNA damage marker and 25-hydroxyvitamin D [25(OH)D] were measured in all study subjects. Total of 410 apparently healthy volunteers were enrolled in this study. According to smoking habit, 170(41.4%) of the participants were found smokers and 240(58.6%) were non-smokers. Significantly higher 8-OHdG (P<0.001), together with lower 25(OH)D levels(p<0.015) were found in smokers compared to non-smokers. In the smoker group, 8-OHdG negatively correlated with 25(OH)D (r= -0.35,p=0.010). In the non-smoker group, we also observed a negative correlation with 25(OH)D (r= -0.46 p=0.010). Elevated 8-OHdG levels in conjunction with low vitamin D status strongly associated with smoking habit. Efforts to quit smoking with increasing vitamin D levels in this group may help to correct abnormal levels of 8-OHdG and reducing DNA damage.
Keywords: DNA damage, cigarette smoking, vitamin D, male population.
How to Cite this Article
Ali AF, Mahmoud HM, Al-Timimi DJ (2021). Effects of Cigarette Smoking on DNA damage in male population in Duhok (Iraq): Relation to vitamin D status. Int. Res. J. Pub. Environ. Health 8(1):29-32.
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