Association of CYP1A1 and CYP2E1 gene polymorphisms with prostate cancer in a Lebanese population

Abstract

The present study investigates the association of the genetic polymorphisms of  cytochromes P450 (CYP) 1A1 and 2E1 with prostate cancer (PCa), which is among  the most common cancers in Lebanon and many countries. Prostate cancer is a multifactor disease where genetic polymorphisms of genes involved in carcinogen metabolism such as CYP1A1 and CYP2E1 could play a key role. Regarding the association of these genes polymorphisms with PCa, case-control studies as well as meta-analyzes investigations reported conflicting results in diverse populations. We conducted the present case-control study to assess whether the alleles CYP1A1*2A (6235T>C) and CYP2E1*6 (7632T>A) are associated with PCa in Lebanon and to compare with polymorphism in other populations. Our results showed that CYP1A1*2A allele was associated with PCa (P= 0.016) and that individuals carrying at least one CYP1A1*2A allele present 2.7-fold increase of PCa risk (P= 0.038). On the contrary, the CYP2E1*6 allele was not significantly associated with this cancer in the studied population despite a clear difference of genotype distribution between patients and controls. We conclude that CYP1A1*2A is among the genetic risk factors that contribute to PCa occurrence in Lebanon.

Keywords: Case-control study, cytochromes P450, human, genetic polymorphism, prostate cancer, RFLP.