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Chuluunbaatar ErdenechimegBuyantogtokh Dejidmaa
Ganbaatar Narangere
Chimedtseren Chimedragchaa
Original Research Article
Protective effect of Monflu on lipopolysaccharide-induced acute lung injury in Wistar rats
Chuluunbaatar Erdenechimeg1, Buyantogtokh Dejidmaa*2, Ganbaatar Narangerel2 and Chimedtseren Chimedragchaa1
1Department of Pharmacy, Institute of Traditional Medicine and Technology, Ulaanbaatar, 17032, Mongolia
2Department of Pharmacology, Institute of Traditional Medicine and Technology, Ulaanbaatar, 17032, Mongolia
*Corresponding Author Email: b.dejidmaa(at)yahoo.com
Tel.: (976) 99125890
Chuluunbaatar Erdenechimeg |
Buyantogtokh Dejidmaa |
Ganbaatar Narangere |
Chimedtseren Chimedragchaa |
Article Number: ibspr.23.001 | Pages: 1-8 | Vol. 12(1), March 2024 | DOI: https://doi.org/10.15739/ibspr.24.001
Received: December 4, 2023 Accepted: January 19, 2024 Published: March 4, 2024
Abstract
Monflu is a granule that develops from Lider-7 traditional prescription, and used for the treatment of respiratory contagious diseases. This study aimed to evaluate quality control, total biological activity and to analyze the activity of this substance in Wistar rat with acute lung injury (ALI). Seventy Wistar rats were randomized into four groups as follows: control group, Lipopolysaccharide (LPS) group, and LPS+Monflu groups (242 mg/kg and 484 mg/kg Monflu before LPS injection). Results showed that, Monflu contained 6g granule in a packet, alkaloids were 95±16.6 µg/g, phenols were 3.36±0.45 mg/g, flavonoids were 1.18±0.1 mg/g. The rats pretreated with Monflu high and low doses had significantly decreased levels of interleukin (IL)-1β (p=0.001 at 3-12 h), IL-6 (p=0.001 at 9 and 12 h) and tumor necrosis factor (TNF)-α (p=0.05 at 9 and 12 h). The rats pretreated with Monflu groups significantly increased levels of prostaglandin E2 (PGE2) at 3, 6, and 9 h (p<0.05), but it had reduced at 12 hours (p=0.001). Monflu groups showed significantly decreased inflammation and change of pulmonary structure. This study showed that Monflu exhibited a protective effect against LPS-induced ALI which was revealed to be mediated by suppressing the release of pro-inflammatory cytokines.
Keywords: Traditional medicine, herbal granule, total alkaloid, acute lung injury, lipopolysaccharide, monflu, inflammatory cytokines
How to Cite this Article
Erdenechimeg C, Dejidmaa B, Narangerel G Chimedragchaa C(2024). Protective effect of Monflu on lipopolysaccharide-induced acute lung injury in Wistar rats. Issues in Biological Sciences and Pharmaceutical Research.Vol.12(1):1-8. DOI:https://doi.org/10.15739/ibspr.24.001
© 2024 The authors.
This is an Open Access article that is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which allow unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.