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Original Research Article

The preventive effect of grape seeds ethanolic extract as antihyperglycemia against streptozotocin-induced diabetic rats

1*Nermien Z. Ahmed, 2Fouad A. Ahmed, 2Moustasfa A. A. and 1Dalia A. Hashim


1National Organization for Drug Control & Research “NODCAR”; Department of Molecular Drug Evaluation, Giza, Egypt. 2Faculty of Agriculture, Cairo University, Department of Biochemistry, Giza, Egypt.

*Corresponding Author Email: nermienteleb(at)yahoo.com Tel.: (020) 01223740700; 01069194681.


Article Number:  |   Pages:  |     |   DOI:

 Received: May 25, 2016  Accepted: July 14, 2016  Published: July 28, 2016

Abstract

This study aim to determine the protective effect of Grape seeds (Vitis vinifera) ethanolic extract against streptocotozin-induced diabetic rats. Sterptozotocin was used by (50mg/kg b.w. i.p.); Vitis vinifera seeds were used at (100 & 200 mg/kg b.w. oral) daily/ three weeks.  The result indicated that Sterptozotocin increased the levels of serum glucose; uric acid; creatinine; ALP; ALT and AST, blood urea, and decreased the activities of SOD and GSH-Px, after treated with grape seeds by the high dose show a significantly decreased in levels of serum glucose; uric acid; creatinine, ALP; ALT and AST, urea. On the other hand, SOD and GSH-Px activities exerted a highly increase in diabetic rats given with the extract. Also, it can be speculated that Grape seed (Vitis vinifera) ethanolic extract has a hypoglycemic effect possibly related to the phytochemical compounds of Vitis vinifera plant seeds include Gallic acids, Catechin, Ρ-hydroxy bezoic acid, Vanillin, Ferulic acid, Ρ-Coumaric acid, Euganol , as well as, 5,7- dihydroxy 4-methoxy isoflavone which can optimize sugar uptake in the liver. These feats could induce insulin secretion and release from cells, as well as stimulates the tissue’s insulin sensitivity leading to an increase of the tissues’ glucose uptake, storage, and oxidation.

Keywords:

DPPH, Antioxidant, Lysosomal enzymes, Grape seeds (Vitis vinifera) extracts, Sterptozotocin

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