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Original Research Article

Hypoglycaemic efficacy and phytochemical screening of fruits ethanolic extract of solanum terminale forsk (solanaceae)

Rajabu M. Kingo*1,2, Sheila M. Maregesi2 and Abdul W. Kidukuli2


1Department of Biomedical Sciences, College of Health Sciences, The University of Dodoma, P.O. Box 395 Dodoma, Tanzania.
2Department of Pharmacognosy – School of Pharmacy, Muhimbili University of Health and Allied Sciences.P.O. Box 65013 Dar Es Salaam, Tanzania.

*Corresponding Author Email: rajkingo(at)yahoo.com

Tel.: +255 715 565 620

Rajabu M. Kingo

Sheila M. Maregesi

Abdul W. Kidukuli


Article Number: ibspr.20.004  |   Pages: 37-42  |   Vol.8 (2), April 2020   |   DOI: https://doi.org/10.15739/ibspr.20.004

 Received: January 6, 2020  Accepted: March 5, 2020  Published: April 8, 2020

Abstract

This study aimed at screening for the hypoglycaemic efficacy and phytochemical(s) of Solanum terminale fruits, being used traditionally in Lushoto, Tanzania for management of diabetes and hypertension. S. terminale fruits were collected November 2018 in Lushoto. Hypoglycaemic efficacy testing of the crude ethanolic extract and factions of S. terminale fruits at 100 mg/kg body weight (BW) dose were carried out in healthy albino mice using Oral Glucose Tolerance Test (OGTT). The phytochemical screening based on the chemical reactions of the precipitation and coloration with the standard reagents was used. The statistical analysis of results was carried out using independent student’s t-test (p ˂ 0.05). The crude ethanolic extract and fractions of S. terminale fruits at a dose of 100 mg/kg BW have demonstrated the significant blood glucose lowering efficacy, and the phytochemical screening indicated the presence of tannins, saponins, terpenoids, alkaloids, steroids, flavonoids and glycosides. Results of the study indicate the therapeutic potential of S. terminale fruits in the lowering of the blood glucose levels, but further studies are needed including toxicity and other animal models testing for diabetes.

Keywords:

Oral glucose tolerance test, hypoglycaemic, S. terminale, diabetes management

How to Cite this Article

Kingo RM, Maregesi SM Kidukuli AW(2020). Hypoglycaemic efficacy and phytochemical screening of fruits ethanolic extract of solanum terminale forsk (solanaceae).Issues Biol. Sci. Pharma. Res.8(2):37-42

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