Issues in Biological Sciences and Pharmaceutical Research

Original Research Article

Assessment of the antipyretic, and anti-inflammatory effects of Zanthoxylum Zanthoxyloides stem bark aqueous extract on Wistar rats

Tougoma Atèhèzi*1,3,4, Atchrimi S. Komi,3,4, Dénou Adama2,3,5, Idah V. Oto-Obong1, Egesie U. Gideon1 and Odeh O. Samuel1


1Department of Human Physiology, Faculty of Basic Medical Sciences, University of Jos, Plateau State-Nigeria. P. M. B. 2084, Jos, Plateau State-Nigeria.
2Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, University of Jos, P. M. B. 2084, Jos, Nigeria.
3Africa Centre of Excellence in Phytomedicine Research and Development (ACEPRD), University of Jos, Plateau State-Nigeria. P. M. B. 2084, Jos, Plateau State-Nigeria.
4Centre de Recherche et de Formation sur les Plantes Médicinales, University of Lomé, Lomé-Togo. P. M. B. 1515, Lomé-Togo.
5Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Science, Techniques and Technologies of Bamako, P.M.B 1805, Bamako, Mali.

*Corresponding Author E-mail: tougomabienvenu(at)gmail.com

Tel.: + 234 (0) 813 217 8619 / +228 91 99 29 75.

Tougoma Atèhèzi

Atchrimi S. Komi

Dénou Adama

Idah V. Oto-Obong

Egesie U. Gideon

Odeh O. Samuel


Article Number: ibspr.21.008  |   Pages: 78-85  |   Vol. 8 (3), October 2021   |   DOI: https://doi.org/10.15739/ibspr.21.008

 Received: July 28, 2021  Accepted: September 13, 2021  Published: October 10, 2021

Abstract

This present study was aimed at investigating the antipyretic and anti-inflammatory effects of Zanthoxylum zanthoxyloides stem bark aqueous extract on albino Wistar rats at doses of 400 and 800 mg/kg body weight. Oedema was induced using 0.2 mL of 1% egg albumin and 2% formalin in rats treated with the extract and standard drugs (diclofenac and aspirin respectively). Paw circumference was measured in the experimental groups with Vernier caliper at different times. Fever was induced by subcutaneous injection of 20 ml/kg with brewer’s yeast suspension in normal saline at 20% (w/v) to each rats and treated with the extract and paracetamol. The rectal temperatures were taken hourly for four hours. Significant oedema reduction was observed from the 90th minute after induction with egg albumin and from the 150th minute after induction with formalin. The extract administration provoked significant rectal temperature reduction from the second hour of fever induction until the fourth hours of the experiment. This present study reveals the antipyretic, and anti-inflammatory properties of the stem bark aqueous extract of Zanthoxylum zanthoxyloides.

Keywords:

Zanthoxylum zanthoxyloides, stem bark, aqueous, anti-inflammatory, antipyretic, oedema, rectal temperature, Wistar rats

How to Cite this Article

Tougoma A, Atchrimi SK, Dénou A, Oto-Obong IV, Egesie UG, Odeh OS (2021).Assessment of the antipyretic, and anti-inflammatory effects of Zanthoxylum Zanthoxyloides stem bark aqueous extract on Wistar rats. Issues Biol. Sci. Pharm. Res.9(3):78-85.

Author(s) retain the copyright of this article. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.


Select Language »