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J Zhao
X Zhang
W Xin
W Liu
D Sun
G Yang

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J Zhao
X Zhang
W Xin
W Liu
D Sun
G Yang

International Research Journal of Public and Environmental Health
Vol.3 (2),pp. 20-27, February 2016
ISSN 2360-8803
Available online at https://www.journalissues.org/IRJPEH/
DOI:http://dx.doi.org/10.15739/irjpeh.16.004
Article 16/ID/JPRH003/ 08 pages
Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.



Original Research Article

Risk factors analysis for bacteria discharge of pulmonary tuberculosis

Jiangnan Zhao1, Xiaoqi Zhang2, Wenge Xin2, Wenyu Liu2, Dezhi Sun2 and Guoru Yang*3

1Department of Respiratory Medicine, The First Hospital of Jiaxing, Jiaxing, China.
2Department of Tuberculosis Medicine, Second People’s Hospital of Weifang, Weifang, China.
3Department of Respiratory and Critical Care Medicine, Second People’s Hospital of Weifang, Weifang, China.

*Corresponding Author E-Mail: zjn911016(at)126.com

Tel: +86536-8233405,Fax:+86536-8233405



date Received: January 8, 2016     date Accepted: January 30, 2016     date Published: February 12, 2016


 Abstract

TB patients with bacteria discharge have higher risk of infectivity and spread of TB, but little is known of risk factors for bacteria discharge in the China border region. We aimed to discuss the predictors for bacteria discharge in pulmonary TB (PTB) patients. Over 47-month period a retrospectivestudy was done on 3669 consecutive PTB patients. Predictors of bacteria discharge in PTB were identified by univariate and multivariate logistic regression analysis. The c statistic was calculated to assess the discriminatory ability of the multivariate logistic regression model to predict bacteria discharge. The overall incidence of bacteria discharge in PTB was 32.24%. Underweight (OR 5.14, 95% CI 1.56-16.28), smoking history (OR 2.00, 95% CI 1.12-3.56), cavity (OR 2.57, 95% CI 1.22-8.56), low BMI (OR 1.51, 95% CI 1.05-2.16) and hypoproteinemia (OR 1.58, 95% CI 1.06-2.35) were positively associated and pleural effusion (OR 0.30, 95% CI 0.18-0.48) was negatively associated with bacteria discharge in PTB patients. Underweight, smoking history, cavity, low BMI and hypoproteinemia are the independent factors for TB bacterial discharge. Early identification of PTB patients that susceptible to bacteria discharge may contribute to controlling source of infection in time and reduce the spread of TB.


Key words: Tuberculosis (TB),bacteria discharge, risk factor


Zhao et al