Issues in Biological Sciences and Pharmaceutical Research
Article ID BSPR021,05 pages
Available online at https://www.journalissues.org/IBSPR/
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Original Research Article
Effect of grape juice on some biochemical and oxidative stress parameters in serum and liver enzymes of pregnant and lactating rats
Mariane Farias Wohlenberg1, Luciana Kneib Gonçalves1, Thays Krischke Schaffer1, Daniele Karina Hilger1, Ruben Dario Braccini Neto1, Carolina Antunes1, Marina Frusciante1, Adriana Rodrigues2, Cláudia Funchal1, Caroline Dani1*
1Laboratory of Biochemistry, Methodist University Center IPA, Porto Alegre, Rio Grande do Sul, Brazil;
2Institute of Biotechnology, University of Caxias do Sul (UCS), Caxias do Sul, Rio Grande do Sul, Brazil.
*Corresponding Author E-mail: caroline.dani(at)metodistadosul.edu.br
Tel.:+55 51 3316 1298.
This study aimed to evaluate biochemical and oxidative stress parameters in serum and liver of Wistar rats, in the period after pregnancy and lactation, treated chronically with red grape juice variety Bordo (Vitis labrusca). Forty Wistar rats were placed for mating, and the confirmation of pregnancy was through vaginal swab. After, these animals were randomly divided into 4 groups with and without handling. The groups submitted to handling were treated by gavage (7µL/g) and groups not submitted to handling were treated by free access. Results on this study show that red grape juice reduced the levels of aspartate aminotransferase (liver enzyme) in the serum of the handled animals tested (p<0.05). Regarding the parameters of oxidative stress, red grape juice was able to reduce the levels of protein oxidation in liver and serum of the animals as well as to modulate the enzymatic activity of superoxide dismutase in the liver and the enzymatic activity of catalase in the serum of the same, consequently promoting changes in the relation of these enzymes (p<0.05). Based on the obtained results, it is possible to see the red grape juice V. labrusca benefits presented against the evaluated biochemical and oxidative stress parameters, suggesting it as an important ally in the diet of pregnant women.
Key words: Biochemical markers, hepatoprotection, pregnancy