International Research Journal of Public and Environmental Health
Vol.6 (4),pp. 53-58, July 2019
Available online at https://www.journalissues.org/IRJPEH/
Author(s) retain the copyright of this article. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.
Original Research Article
Hepatotoxicity of radiographic fixer effluent on wistar rats
Anthony Chukwuka Ugwu1, Nkiru Elvina Ignatius2, Michael Promise Ogolodom*3, Beatrice Ukamaka Maduka4, Robert Oziegbe Akhigbe5, Awajimijan Nathaniel Mbaba6 and Oluwafemi Olumide Egbeyemi1
1Radiography and Radiological Sciences Department, Faculty of Health Sciences and Technology, Nnamdi Azikiwe University Anambra State, Nigeria.
2Afe Babalola University Multi-System Hospital Ado-Ekiti.
3Rivers State Hospital Management Board Port Harcourt, Rivers State Nigeria
4Department of Medical Radiography and Radiological Sciences, University of Nigeria Enugu Campus, Nigeria.
5Rovina Medical Diagnostic Services, Lagos State Nigeria
6Department of Radiology, Rivers State University Teaching Hospital, Port Harcourt Rivers State, Nigeria
*Corresponding Author Email: mpos2007(at)yahoo.com
This study was designed to evaluate the hepatotoxicity of radiographic fixer effluent on Wistar rats. Fourteen Wistar rats of weights 140-220g were divided into three groups; the control group (I) and experimental groups(II and III).The control group was further divided into groups of two rats each and administered 1ml of distill water daily orally for 14 and 28 days respectively, each of the experimental groups II and III were further sub-divided into two groups of two and three rats each respectively (i.e. group IIA, 2 rats, group IIB 3 rats and group IIIA 2 rats and group IIIB 3 rats), and were orally administered with 200mg/kg and 400mg/kg of fixer effluents daily for 14 days and 28 days respectively. Histopathological result showed normal liver tissues in the control group; liver tissue with hypertrophied (distended) central vein in groups II A and II B; normal hypatocytes, interstitial tissues and distended central with mild infiltrate of edematous fluid with long term experimental group; liver tissue enlarged central vein with indication of edematous infiltrate accumulation within the vein with short term experimental group .The present study showed that long and short-term oral administration of low dose fixer effluent, as well as short-term administration of high dose of fixer caused changes in the histological patterns of a healthy Wistar rats’ liver.
Key words: Effluent, fixer, hepatotoxicity, liver