Issues in Biological Sciences and Pharmaceutical Research
Vol.2(5),pp .040-044, June 2014
Article ID BSPR012/14/ 05 pages
Copyright © 2014 Author(s) retain the copyright of this article. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 3.0 International License
Original Research Paper
Effects of silver nanoparticle (Ag NP)on oxidative stress, liver function in rat: hepatotoxic or hepatoprotective?
Accepted 30 April, 2014
Tavakol Heidary Shayesteh1,Farzad Khajavi2, Hassan Ghasemi3, Seyed-Mostafa Hossini Zijoud 3, and Akram Ranjbar1*
1Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
2Department of Chemistry, Bu-Ali Sina University, Hamedan, Iran
3Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding Author Email: firstname.lastname@example.org
Tel/Fax: +98 811 8380031
Silver nanoparticles (Ag NPs) have been widely used as new potent antimicrobial agents in cosmetic and hygienic products. The purpose of this study was to investigate the possible protective role of Ag NP antioxidative biomarkers ?? ?in rat liver. Rats received Ag NP, 5, 50, 250 and 500 mg/kg/day IP. After two week of treatment, the activity of catalase (CAT), total antioxidant capacity (TAC) and total thiol molecules (TTG) in liver tissue were measured. Then ALT (alanine aminotransferase ) and ALP(alkaline phosphatase) activities in blood were measured. Ag NP in 5, 50mg/kg reduced activities of CAT, ALT and increased TAC and TTG in liver homogenate compared Ag NP 500mg/kg/day group. Also, in this study, Ag NP with 500mg/kg/day induced activities of CAT, AST and ALT compared control group. It is considered Ag NP beneficial effects for the protection oxidative liver injury in low doses and considered toxic in high doses.
Key words: Silver nanoparticle (Ag NP), oxidative stress, rat, liver