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S Nikpour
M Kazempour
L Gachkar
S Sabeti
M Salehi

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S Nikpour
M Kazempour
L Gachkar
S Sabeti
M Salehi

International Research Journal of Medicine and Biomedical Sciences
Vol.1 (4),pp. 34-37, September 2016
ISSN 2488-9032
Available online at https://www.journalissues.org/IRJMBS/
DOI:http://dx.doi.org/10.15739/irjmbs.16.007
Article 16/ID/JMBR033/ 04 pages
Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.



Original Research Article

Is there an association between Helicobacter pylori infection and alteration of lipid and glucose serum levels after elimination of secondary causes?

Shahriar Nikpour1#, Muhanna Kazempour2*# Latif Gachkar3#, Shahram Sabeti4# and Mohammad Salehi2#

1Department of Gastroenterology and Liver Diseases, Shahid Beheshti University, Tehran, Iran.
2Department of Internal Medicine, Shahid Beheshti University, Tehran, Iran.
3Department of Infectious Disease and Tropical medicine, Shahid Beheshti University, Tehran, Iran.
4Department of Pathology, Shahid Beheshti University, Tehran, Iran.

*Corresponding author. Email: muhannakazempour(at)gmail.com

#All authors contributed equally to this study.

Tel: +982122439982;
Fax: +982122439784.



date Received: August 4, 2016     date Accepted: August 21, 2016     date Published: August 30, 2016


 Abstract

Helicobacter pylori colonizes the stomachs of 50% of the world’s human population throughout their lifetimes. Recent research has focused on whether H. pylori colonization is a risk factor for some extragastric diseases. This infection may disturb glucose and lipid metabolism in a way that may increase the risk of atherosclerosis. The aim of this study was to assess the association between H. pylori infection and metabolic parameters. This cross-sectional study surveyed anti H. pylori IgG antibodies in 132 healthy check-up subjects in 2015; 125 subjects (43 men and 82 women, age 20–59 years) fulfilled the inclusion criteria. Metabolic parameters were determined by routine blood tests and Body Mass Index (BMI) was also calculated. 68 patients (54.4 %) had serum antibodies to H. pylori. The group (n = 68) of subjects with positive serology for H. pylori differed from the group without positive serology (n = 57) in age (P value <0.03). No significant difference was observed regarding the other parameters such as glucose, lipid and body mass index. Our results are in agreement with those of some studies that had tried to eliminate confounding factors. Subjects with positive serology for H. pylori are characterized by greater age. If confounding factors are taken into account, most authorities consider the associations between H. pylori infection and metabolic parameters to be non-causal.


Key words: Helicobacter pylori, glucose, serum lipid, BMI, metabolic parameters


Nikpour et al