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P Durairaj
J Shan
SC Miller

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P Durairaj
J Shan
SC Miller

Issues in Biological Sciences and Pharmaceutical Research
3(1),pp. 5-13, January 2015
ISSN 2350-1588
Article ID /15/BSPR005/09 page
Available online at https://www.journalissues.org/IBSPR/
DOI:http://dx.doi.org/10.15739/ibspr.007
Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License



Original Research Article

Reversal of alopecia areata in a mouse model of human hair loss by daily dietary administration of a proprietary extract of North American ginseng (Panax Quinquefolius): Maintenance of hair after extract withdrawal

1Durairaj Punithavathi, 2Shan Jacqueline J. and 1*Miller  Sandra C.

1Department of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.
2Afinity Life Sciences, Inc., Edmonton, Alberta, Canada.

*Corresponding Author E-mail: sandra.miller(at)mcgill.ca
Tel: 514-398-6358
Fax: 514-398-5047



date Received:     date Accepted: February 11, 2015     date Published:


 Abstract

Decades of study on alopecia areata have concluded that the condition results from an autoimmune attack on the hair follicle growth center (anagen).  In this study, we have used C3H mice, the established model of human alopecia areata. Elderly mice (18 months), almost completely alopecic, were placed on a daily conventional diet (6gm chow/mouse) for 32 weeks (8 months), into  which 80mg/mouse of CVT-E002 (a proprietary extract of North American ginseng), was homogenized.  These mice began to show hair re-growth after only 2 weeks, with complete hair re-growth by week 32 at which time they were euthanized. The absolute numbers (x106) of natural killer (NK) immune cells, and of non-NK immune cells (T/B lymphocytes) in mice consuming CVT-E002, were significantly more abundant (p< 0.0001) in both the spleen and bone marrow than in the corresponding organs of parallel, control-diet alopecic mice.  In a second group of experiments, CVT-E002 was removed from the diet at week 32 and mice were placed on the control diet for the following 14 weeks (3½ months).  All these mice retained their fully re-grown coats. At that time, mice were aged 29 ½ months (2½ years), i.e., 80- 90 years of age in humans.


Key words: ginseng, NK cells, lymphocytes, alopecia areata, pre-clinical


Miller et al