All Issues
Current Issue

.Reprint (PDF) (1,079 KB)

Search Pubmed for articles by:

T Liu
C Zong
G Liu
X Liu
X Liu
W Liu
X Wang
Q Yu

Search Google Scholar for articles by:

T Liu
C Zong
G Liu
X Liu
X Liu
W Liu
X Wang
Q Yu

International Research Journal of Public and Environmental Health
Vol.2 (11), pp. 174-181, November 2015
ISSN 2360-8803
Available online at https://www.journalissues.org/IRJPEH/
DOI:http://dx.doi.org/10.15739/irjpeh.036
Article 15/ID/JPRH087/ 06 pages
Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.



Original Research Article

Association of 24 hour urinary sodium, potassium and ALDH2rs671, MTHFRrs1801133 polymorphisms with blood pressure in isolated Zhangzi Island population

Tonghanyu  LIU, Chengguo ZONG, Guanhong LIU, Xintao LIU, Xin LIU, Wenzhi LIU, Xingyu WANG and Qin YU

1Dalian University, Dalian 116622
2Clinical Lab, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001
3Health center of Dalian Zhangzi Island, Dalian 116503
4Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing 100043
5Affiliated Zhongshan Hospital of Dalian University, Dalian 116001
6Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001

*Corresponding Authors Email: dryuqin060621(at)sina.com
Tel: +86-411-62893517
Fax: +86-411-62893555



date Received: October 7, 2015     date Accepted: October 27, 2015     date Published: November 6, 2015


 Abstract

The purpose of this study is to investigate the association of morning fasting urinary sodium, potassium and genetic background on ALDH2rs671 and MTHFRrs1801133 polymorphisms with blood pressure in Chinese Zhangzi Island population. In this study, we used fasting morning urine to estimate the 24 hour sodium and potassium intake and to test the association with blood pressure in a total of 180 randomly recruited subjects from Zhangzi Island. Beyond the sodium intake, genetic background of ALDH2rs671 and MTHFRrs1801133 polymorphisms was also tested for the association with blood pressure in this population. Zhangzi islanders were randomly recruited for the health checkup in local community hospital,  each individual was measured for blood pressure and related metabolic traits (triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), fasting morning urinary sodium, potassium and creatinine. We used the Kawasaki formula to estimate 24h urine sodium and potassium excretion to investigate the association between estimated urine sodium, potassium excretion and blood pressure. According to the adjusted WHO-Monica investigation questionnaire, we obtained the demographic information including sex, age, height, weight, alcohol intake history. Genomic DNA was extracted from whole blood. The ALDH2rs671 and MTHFRrs1801133 polymorphisms were genotyped by the TaqMan real-time polymerase chain reaction assay. After removed the outliers of the estimated 24h urinary sodium and potassium, we found a positive association between  Systolic Blood Pressure (SBP),  Diastolic Blood Pressure (DBP) and estimated 24h urinary sodium (SBP: β=0.157, P<0.05; DBP: β=0.203, P<0.05) with adjustment for age, sex, Body Mass Index (BMI). We found ALDH2rs671 is significant associated with SBP (P<0.05) after adjustment for sex, age, BMI, alcohol intake history and estimated 24h urinary sodium, and ALDH2rs671 is also associated with TC, LDL-C (both P<0.05), but no association was found in MTHFRrs1801133 genotypes in blood pressure or other metabolic traits in these high salt intake islanders. We found that 24h urine sodium excretion is significantly associated with both SBP and DBP; polymorphism of ALDH2rs671 is also associated with SBP, TC and LDL-C in this isolated population.


Key words: urinary sodium, blood pressure;, ALDH2rs671, MTHFRrs1801133, urinary potassium


Liu et al