Issues in Biological Sciences and Pharmaceutical Research
Vol.3 (8),pp.78-85, August 2015
Article ID /15/BSPR022/08 pages
Available online at https://www.journalissues.org/IBSPR/
Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.
Original Research Article
Anomerism differentiates the interfacial property of galactolipid-doped phospholipid monolayers
Danyang Liu, Wanluo Wang, Xiao-Peng He,* Guo-Rong Chen, Shouhong Xu* and Honglai Liu
Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai 200237, PR China.
*Corresponding Author E-mail: xushouhong(at)ecust.edu.cn,xphe(at)ecust.edu.cn
Tel: 8021 64251942
Fax: 8021 64252921
Anomerism is a common feature of nearly all glycoconjugates. However, the impact of anomerism on their functional diversities has been rarely investigated. In our opinion, glycoconjugates are expected to dope into liposomes or vesicles for adjusting property or function. In this paper, we investigated comparatively the interfacial behaviour of a phospholipid separately doped with a pair of anomeric (α- or β-) galactolipid by using the Langmuir-Blodgett technique. The β-galactolipid was found to be more erective than the α-counterpart at the air-water interface. The molecular interaction of the α-galacto-monolayer might be stronger than the β-counterpart. Results showed an unprecedented observation that anomerism can largely impact the properties of glycolipid embedded phospholipid monolayers. The intermolecular interaction and phase state of the mixed membranes had significant influence on their interfacial behaviours. This study offers a useful insight into the more sophisticated development of these functional glyco-materials.
Key words: Interfacial behaviour, biomembrane, glycolipid, langmuir-Blodgett technique