Issues in Biological Sciences and Pharmaceutical Research
Vol.4(1),pp.1-5 January 2016
Available online at https://www.journalissues.org/IBSPR/
Author(s) retain the copyright of this article. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.
Original Research Article
Toxicological evaluation of five brands of Artemether-Lumefantrine drugs in male albino Wistar rats
1*Etim, O.E., 1Ndem, J. I., 1Ewere, E.G. and 1Bassey, U.E.
1Department of Biochemistry, University of Uyo, P.M.B. 1017, Uyo, Nigeria
*Corresponding Author Email: betobong123(at)yahoo.com
Comparative effects of five different brands of Artemether-Lumefantrine antimalaria drugs on liver and kidney function parameters and haematological indices in male albino Wistar rats were investigated. The medications were Coartem, Lumartem, Combiart, Amatem forte and Famter. Thirty (30) male albino Wistar rats with average weight of 155g were used. They were divided into six groups of five rats each. Therapeutic doses of artemether-lumefantrine were administered orally for three days at 8mg/kg body weight (bw). The results showed that significant (P<0.05) decrease occurred in total bilirubin in all the treated groups, and in aspartate aminotransferase (AST) in groups treated with Amatem forte and Famter when compared with control. Significant (P<0.05) decrease occurred in red blood cell (RBC) count, haemoglobin concentration (HGB), haematocrit (HCT) in groups treated with Coartem and Lumartem while mean cell volume (MCV) and mean cell haemoglobin (MCH) decreased significantly (P<0.05) in groups treated with Coartem alone. Significant (P<0.05) decrease also occurred in chlorine alone in all the treated groups except in group treated with Coartem. Some brands of medications appeared not to be deleterious to tissues except Coartem and Lumartem which seem to cause haematological derangements. Hence, caution in their usage is advised.
Key words: Artemether-Lumefantrine combination, haematological adverse effect, kidney function, liver function