Issues in Biological Sciences and Pharmaceutical Research
Article ID/15/BSPR/021/05 pages
Available online at https://www.journalissues.org/IBSPR/
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Original Research Article
High prevalence and multidrug resistance of Acinetobacter baumannii among patients after liver transplantation
Iman M.A. El-Kholy*1,Amin Abdo2 and Helmi M. Abdel Aziz3
1Ain Shams University Specialized Hospital, Cairo, Egypt.
2Gomohory Hospital, Ministry of Health, Yemen.
3Microbiology and Botany Department, Faculty of Science, Suez Canal University, Ismailia, P.O. 41522, Egypt.
*Corresponding Author Email: imankholy(at)yahoo.com
This study aimed to overview the problem of prevalence of multidrug resistance of A. baumannii and other bacteria causing nosocomial infections in patients after liver transplantation to determine the risk factors predisposing to these infections. In total, 131 consecutive patients who underwent liver transplantation between January 2012 to March 2013, 133 isolates of bacteria from 88 patients has been identified by MicroScan® microbiology, API20 and polymerase chain reaction. Furthermore fungal infections also been identified. Bacterial infections represented the most frequent infections. The most common site of pathogen isolation overall was the sputum (6 isolates, 40 %), followed by the blood (4 isolates, 26.7%), urinary tract infections (2 isolates, 13.3%), other infection site included wounds (20 %). Acenitobacter baumannii showed multidrug resistance to most screened antibiotics used in thid study where the highest percentage of resistance was (100%) to cefoperazone ,cefoperazone-sulbactam and doxycycline while the most effective antibiotics against bacteria were Imipenem and Imipenem- cilastatin (20%) for each one followed by Merpenem (53%).Patients with Gram-negative bacilli infection after liver transplantation show a significantly worse prognosis. A. baumannii after liver transplantation have been a major problem in our center.
Key words: Acinetobacter baumannii, PCR, multi-drug resistance, transplantation