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 Abstract

Issues in Biological Sciences and Pharmaceutical Research
Vol.1 (2), pp. 022-029, October 2013
ISSN 2350-1561
Article ID BSPR008, 08 pages
Copyright © 2014 Author(s) retain the copyright of this article. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 3.0 International License

Original Research Paper

Synthesis and antimicrobial evaluation of some chalcones

Accepted 21 October, 2013

Haruna Baba*1, Odigwe Azubike2 and Cyril O. Usifoh2

1Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, Niger Delta University, Bayelsa State, Nigeria.
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria.

*Corresponding author.E-mail:babharun(at)yahoo.co.uk
Tel.: +2347034402435

 Abstract

Chalcones are ubiquitous in nature and they are precursors to the flavonoids family. Natural occurring chalcones as well as synthetic chalcone analogues have demonstrated many pharmaceutical effects, including anti-inflammatory, anti-oxidant, anti-parasite, and anti-tumor activities . The synthesis of some substituted chalcones was carried out in alcoholic potassium hydroxide at room temperature by Claisen-Schmidt condensation reaction. The compounds were obtained in good yield and were characterized using the combination of IR and NMR spectroscopy. The antibacterial activity of the synthesized compounds was carried out and they were found to be inactive against the tested strains of micro-organisms. Contrary to the popular belief that most chalcones do exhibit antimicrobial activity, these substituted chalcones lack such activity.

Key words: Chalcones, antibacterial activity, micro-organism


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