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H Awadallah
M Shaker
K Gaber
K Amr

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H Awadallah
M Shaker
K Gaber
K Amr

International Research Journal of Public and Environmental Health
Vol.5 (1),pp. 8-12, January 2018
ISSN 2360-8803
Available online at https://www.journalissues.org/IRJPEH/
DOI:https://doi.org/10.15739/irjpeh.18.002
Article 17/ID/JPRH124/ 05 pages
Author(s) retain the copyright of this article. Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.



Original Research Article

The role of obesity in JAK2 V617F gene mutation among patients with recurrent pregnancy loss

Hala Awadallah*1, Mai Shaker2, Khaled Gaber2 and Khalda Amr3

1Institute of Environmental Studies and Reasearch Ain Shams University,Egypt.
2Prenatal Diagnosis and Fetal Medicine Department National Research Centre, Medical Molecular Genetics department National Research Centre, Egypt.
3Prenatal Diagnosis and Fetal Medicine Department National research Centre

*Corresponding Author Email: hala_awadalla(at)yahoo.com



date Received: November 4, 2017     date Accepted: December 18, 2017     date Published: January 31, 2018


 Abstract

Maternal obesity is one of the factors that have a role in recurrent pregnancy loss (RPL). This research deals with fetal loss in obese pregnant women that might be due the mutation in Janus kinase2 gene (V617F). The main purpose of this article is to explore the association of obesity with JAK2 V617F mutation in recurrent pregnancy loss. This study is carried out on 250 women, the case group with a history of recurrent pregnancy loss and a body mass index (BMI) >24.9kg/m2. Control group consists of women with normal body mass index and have at least one live child and with no history of pregnancy loss. All subjects were investigated for the mutations by using the allele-specific multiplex PCR. Women in the study who were obese and tested positive for JAK2 V617F were 14 %. 9.3% of patients in the case had a BMI with mean of 30.9 ±4.3. In conclusion the study suggests a correlation between the increased risk for the occurrence of RPL in obese women and the investigated V617F mutation in the Jak2 gene exon 12, this research demonstrates the feasibility that obesity could be a modifiable risk factor for that somatic mutation.


Key words: RPL, Obesity, Gene (V617F)


Awadallah et al