Issues in Biological Sciences and Pharmaceutical Research
Article ID /15/BSPR032/ 08 pages
Available online at https://www.journalissues.org/IBSPR/
Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License
Original Research Article
The use of Onion (Allium cepa L.) treatment can mitigate gastric mucosal injury in rats
Department of Pharmacognosy and Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, P.O. Box 2457, King Saud University, Riyadh 11451, Saudi Arabia.
Author E-mail: sqasoumi(at)yahoo.com
Tel: (+966) 11-4695784;
Fax: (+966) 11-4677710
Onion (Allium cepa L.) is one of the most widely consumed culinary vegetables globally. Onions are a rich source of dietary flavonoids and other bioactive compounds. Its consumption offers protection against a wide range of gastrointestinal disorders. We used a rat model with gastric mucosal injury to simulate gastric ulcer disease in humans by triggering ulcers using various agents such as indomethacin, pylorus ligation, hypothermic restrainment and necrotizing agents (80% ethanol, 0.2 mol/L NaOH and 25% NaCl). Pre-treatment of rats with onion suspension (200 and 500 mg/kg) significantly mitigated enhanced ulcer index elicited by indomethacin, pylorus ligation, hypothermic restrainment and necrotizing agents. Furthermore, hypothermic restrainment-induced intraluminal bleeding was significantly attenuated by administration of onion suspension. Onion treatment significantly modulated changes in non-protein sulfhydryl and malondialdehyde levels of gastric tissue triggered by 80% ethanol. The biochemical findings were supported by an evaluation of stomach histopathology. The present data show that onion confers robust cytoprotection against gastric mucosal damage by a mechanism that is redox-sensitive. Dietary consumption of onions may, thus be beneficial against gastric ulcers in humans.
Key words: Gastric ulcer, folk medicine, onions, antioxidant, cytoprotection, antiulcer.