International Research Journal of Public and Environmental Health
Vol.2 (10),pp. 135-143,October 2015
Available online at https://www.journalissues.org/IRJPEH/
Article 15/ID/JPRH069/ 09 pages
Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License.
Original Research Article
Association of CYP1A1 and CYP2E1 gene polymorphisms with prostate cancer in a Lebanese population
Ziad Abdel-Razzak1*, Houssein Al-Attrache1,2 and Ghina Rammal1
1Laboratory of Applied Biotechnology: Biomolecules, Biotherapy and Bioprocesses (LBA3B), AZM Center-Tripoli and EDST-PRASE-Beirut, Rafic Hariri Campus – Lebanese University, Lebanon.
2Inserm U991, Rennes-1 University, Faculty of pharmacy, Rennes, France.
*Corresponding Author E-mail: ziad.abdelrazzak(at)ul.edu.lb
Tel.:+961 3 48 69 15
Fax +961 5 46 07 96
The present study investigates the association of the genetic polymorphisms of cytochromes P450 (CYP) 1A1 and 2E1 with prostate cancer (PCa), which is among the most common cancers in Lebanon and many countries. Prostate cancer is a multifactor disease where genetic polymorphisms of genes involved in carcinogen metabolism such as CYP1A1 and CYP2E1 could play a key role. Regarding the association of these genes polymorphisms with PCa, case-control studies as well as meta-analyzes investigations reported conflicting results in diverse populations. We conducted the present case-control study to assess whether the alleles CYP1A1*2A (6235T>C) and CYP2E1*6 (7632T>A) are associated with PCa in Lebanon and to compare with polymorphism in other populations. Our results showed that CYP1A1*2A allele was associated with PCa (P= 0.016) and that individuals carrying at least one CYP1A1*2A allele present 2.7-fold increase of PCa risk (P= 0.038). On the contrary, the CYP2E1*6 allele was not significantly associated with this cancer in the studied population despite a clear difference of genotype distribution between patients and controls. We conclude that CYP1A1*2A is among the genetic risk factors that contribute to PCa occurrence in Lebanon.
Key words: Case-control study, cytochromes P450, human, genetic polymorphism, prostate cancer, RFLP.